Description
THE SCIENCE, SIMPLIFIED
How GLP-3 (RT) Works
Triple-Receptor Agonism
GLP-3 (RT) / LY3437943 is a 39-amino acid triple agonist peptide that simultaneously activates GIP, GLP-1, and Glucagon receptors. This multi-receptor approach addresses weight management through three complementary pathways, offering potentially superior efficacy compared to single or dual agonists.
Primary
GIP Receptor
Gastric Inhibitory Polypeptide
- Enhances insulin secretion
- Improves fat metabolism
- Synergizes with GLP-1
Primary
GLP-1 Receptor
Glucagon-Like Peptide 1
- Reduces appetite signaling
- Slows gastric emptying
- Promotes satiety
Supportive
Glucagon Receptor
Glucagon Signaling
- Increases energy expenditure
- Mobilizes fat stores
- Enhances thermogenesis
CLINICAL EVIDENCE
What Research Has Shown
Summary of preclinical and clinical findings
Key Research Findings
Observed Effects
| Appetite suppression | Enhanced via GLP-1 |
| Energy expenditure | Increased via glucagon |
| Insulin sensitivity | Improved via GIP |
| Fat mobilization | Enhanced |
SAFETY DATA
Safety Profile from Research
What clinical studies report
Nausea
MILD-MOD
Vomiting
MILD
Diarrhea
MILD
THEORETICAL CONCERNS
GI side effects common with GLP-1 class
Gastrointestinal side effects are the most common adverse events with GLP-1 receptor agonists. These are typically dose-dependent and tend to diminish over time.
COMPOUND DETAILS
Compound Information
What Is GLP-3 (RT)?
GLP-3 (RT), also known as LY3437943 or Retatrutide, is a 39-amino acid triple agonist peptide that simultaneously activates GIP, GLP-1, and Glucagon receptors. It represents a next-generation approach to metabolic disease treatment.
| Type | Triple agonist peptide |
| Amino Acids | 39 |
| Targets | GIP, GLP-1, Glucagon receptors |
| Developer | Eli Lilly |
Stability Information
Lyophilized powder
-20C – stable long term
Reconstituted
2-8C – use within 30 days
RESEARCH STATUS
Where It Stands
| Clinical stage | Phase 3 active |
| Primary research | Weight management / T2D |
| Developer | Eli Lilly and Company |
| Regulatory status | Investigational |
Frequently Asked Questions
Common questions about GLP-3 (RT) research
Sources & References
Peer-reviewed research
IMPORTANT RESEARCH NOTICE
Not for human consumption. This product is sold exclusively for research and educational purposes.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.
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